Canine Diabetes Wiki
Betasint Bovine Corriente
R, Neutral by Beta Laboratorios
U40, U80, U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h
Line: Betasint
Also known as: Beef R, beef neutral
Similar to: Insuvet Neutral, Hypurin Bovine Neutral
Iletin R, Hypurin Vet Neutral
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze,
Cartridges in use are not to be refrigerated
May be used intravenously

Betasint logo. Bovine insulin was successfully extracted in January 1987-porcine followed in June of the same year.

Betasint Bovine Corriente [1][2] is a short-acting soluble bovine insulin made by Beta Laboratorios. Hypurin Bovine Neutral [3] is a comparable insulin made by CP Pharma; [4][5] both have had nothing added to change its speed or length of activity.

Comparable insulins for veterinary use were Insuvet Neutral, made for Pfizer Animal Health, UK; Hypurin Vet Neutral; both are no longer being offered.[6][7][8]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [9] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [10]

The very small insulin particles in semilente insulin are suspended by zinc. [9] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [11][12] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [9]

R/Neutral Insulins[]


  1. Betasint Bovine Corriente. Beta Laboratorios.
  2. Google Translation of Betasint Bovine Corriente page.
  3. Patient Information-Hypurin Bovine Neutral. NetDoctor UK.
  4. Hypurin Bovine Neutral. Wockhardt UK.
  5. Prescribing Bovine Insulin.
  6. Discontinuation of Insuvet Insulins. My Online Vet UK.
  7. Insuvet Discontinuation. VioVet UK.
  8. Pfizer insulin products currently unavailable. Veterinary News (29 October 2010).
  9. 9.0 9.1 9.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  10. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  11. Deckert T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  12. Resource Guide. American Diabetes Association (2005).

Related pages
Lilly human insulins1992charts
Cp wockhardt bovine insulins
89 main
Iletin R
Hypurin Bovine Neutral
Insuvet Neutral
Hypurin Vet Neutral