Canine Diabetes Wiki
PZI by BCP Veterinary Pharmacy
U40, U50, U100 protamine
Action in dogs:
  • onset 8-20h,
  • peak Xh,
  • duration Xh rarely used [1][2]
Line: N/A
Also known as: Beef PZI
Similar to: Hypurin Vet Protamine Zinc in U100 strength,

Hypurin Bovine Protamine Zinc in U100 strength,
Insuvet Protamine Zinc in U100 strength,

Use and Handling:
Shelf Life: 6 months Type: cloudy
When Opened: XX days
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze, store at 2-8C, Resuspend
Do not use if product does not re-suspend 
Do not use intravenously [3]
Human Activity Profiles Various Insulins

BCP PZI is all bovine; its activity profile would be similar to that of Hypurin Bovine PZI, shown here.

BCP PZI is a bovine-origin PZI-based compounded insulin. Because it's beef based, its amino acid chain is almost the same as that of a cat, so it's especially well-matched to cats. PZI is rarely used in dogs but is considered when other insulins are not effective. [4] Like other insulins, BCP PZI is nrmally administered twice a day. The insulin is made exactly as Lilly did when it was still producing pure beef Protamine Zinc insulin. [5]

To obtain BCP PZI, your veterinarian calls or faxes a prescription (a script) to the phone numbers shown on the BCP Internet site (see the source information below). After the script is placed, you call BCP with a credit card number and BCP ships the insulin to you overnight for delivery Tuesday through Friday. If you want the insulin left without a delivery signature, you should ask BCP for that.

Your vet can order BCP PZI in a U40, U50, or U100 formulation. Some BCP PZI users have their vets order the U40 or U50 strengths and they convert units [6] to administer it in a U100 syringe. BCP PZI is available in 5ml and 10ml vials. A recent price of a 10ml 40U bottle was $29, plus $11 shipping ($40 total).

Shelf life: 6 months.

Handling: You should refrigerate BCP PZI when it is not in use. If you happen to leave it out for one night, most report no problems.

Technical details[]

PZI contains more zinc and protamine than NPH/isophane insulin and it is primarily the extra protamine which gives it its long-acting duration.[7] The additional protamine in the suspension [8] must first be broken down by proteolytic enzymes AKA proteases, [9] before the insulin in PZI can be absorbed. NPH/isophane insulin contains less protamine than PZI does and because there's less, it is an intermediate-acting insulin.

No Combining For PZI

Protamine Zinc PZI [10] insulin cannot be combined with other insulins, due to the amount of protamine in the insulin's formula [11][12].


  1. Insulins. North American Veterinary Conference-Clinicians Brief (2005).
  2. Scott-Moncrieff, Catherine (2009). Canine and Feline Diabetes Mellitus I-page 3. Western Veterinary Conference.
  3. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. Nelson, Richard (2006). Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-page 40. OSU Endocrinology Symposium.
  5. Pharmacist Helps Fill Bovine Insulin Need. Veterinary Practice News.
  6. Using U40 Insulin in U100 Syringes: Conversion Information. Medi Vet.
  7. Greco, Deborah (2010). Treating Diabetes Mellitus in Dogs and Cats. Western Veterinary Conference.
  8. Williams, Robert (1968). PZI Insulin--More Protamine Than NPH/Isophane Insulin-Textbook of Endocrinology, 4th edition. W.B. Saunders.
  9. Proteolytic Enzymes. Wikipedia.
  10. DeRuiter, Jack. Excess Protamine in Protamine Zinc Insulin Formula. Auburn University.
  11. Harrower AD, Duncan LJ, Clarke BF. (1975). Comparison of Injection Techniques for Soluble and Protamine Zinc Insulins in Diabetes Mellitus. Practitioner.
  12. UK-Protamine Zinc Insulin (PZI) Binds to Soluble Insulin in Same Syringe. NHS-UK.

Related pages[]

91 main Cp wockhardt bovine insulins Cp wockhardt bovine insulins
Insuvet Protamine Zinc
Hypurin Bovine Protamine Zinc
Hypurin Vet Protamine Zinc