| Actrapid | |
| R,Neutral by Novo Nordisk | |
| short-acting | r-DNA/GE/GM |
| U40, U100 | none |
| Line | Novo |
| Also known as | Novolin R, ReliOn/Novolin R |
| Similar to | |
| Action in dogs |
|
| Use and Handling | |
|---|---|
| Type | soluble |
| Shelf Life | 30 months |
| When opened | 6 weeks room temp. |
| In pen | 6 weeks room temp. |
| Notes |
|
Actrapid in 10 ml vial and 3 ml pen cartridge.
|
Note that some countries have the brand name in U40 strength. | ||
Novo Nordisk's brand of fast-acting insulin[2][3][4][5][6], known as Novolin R in North America[7].
Comparable insulins made by others are: Huminsulin Normal, Humulin R[8] and Humulin S[9][10][11] by Eli Lilly, and Insuman Rapid[12][13] and Winthrop Rapid, both by Aventis.
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed[14] From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer[15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.
The very small insulin particles in semilente insulin are suspended by zinc[16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins[17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin[19].
R/Neutral Insulins
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral, Insuvet Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, ReliOn/Novolin R Umuline Rapide, Umuline Regular Winthrop Rapid | |
References
- ↑ Insulins-North American Veterinary Conference
- ↑ Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Actrapid
- ↑ EMEA Scientific Discussion-Actrapid
- ↑ Prescribing Novo Insulins
- ↑ Actrapid Information from Novo
- ↑ Actrapid-Medguides UK
- ↑ Novolin R
- ↑ Humulin R Regular Human Insulin
- ↑ Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin S
- ↑ Humulin S Prescribing Information
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles
- ↑ Electronic medicines Compendium (EMC) UK-Patient Information Leaflet-InsumanRapid
- ↑ Prescribing Insuman Insulins
- ↑ FDA-Humulin R
- ↑ Auburn University:Insulin Preparations-Regular Insulin
- ↑ Auburn University: Insulin Preparations-Lente
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ Resource Guide 2005-American Diabetes Association
- ↑ Auburn University: insulin Preparations-Lente Insulin
More Information
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK-Insulin Guide
- Insulin therapy for dogs and cats-Dowling-Canadian Veterinary Journal-September 1995
A discussion of regular/neutral/normal insulins.