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− | | colspan="2" style="background:aliceblue; text-align:center;font-size:9pt" |[[R]],[[Neutral]] by [[Novo Nordisk]] |
+ | | colspan="2" style="background:aliceblue; width:300px; text-align:center;font-size:9pt" |[[R]], [[Neutral]] by [[Novo Nordisk]] |
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− | | style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[short-acting]] |
+ | |colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[short-acting]] |
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− | | style="background:#bcd2ee;text-align:center;font-size:9pt" |
+ | | colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[r-DNA/GE/GM]] |
− | | style="background:#bcd2ee;text-align:center;font-size:9pt"|none |
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− | + | ! colspan="1" style="background:#bcd2ee; width:150px; text-align:center;font-size:9pt" | U40, U100 |
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+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Action in dogs:''' |
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− | |colspan="2" style="background:aliceblue;font-size:9pt;text-align:left"| ''' |
+ | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Novo Nordisk|Novo]] |
+ | |- |
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+ | | colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Novolin R]], [[ReliOn/Novolin R]] |
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− | <br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide] |
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|- |
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+ | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' [[Huminsulin Normal]], [[Humulin C]]<br>[[Humulin R]], [[Humuline R]], [[Humulin Regular]]<br>[[Humulina Regular]], [[Humuline Regular]], [[Humulin S]]<br>[[Humulin ReliOn R]], [[Umuline Rapide]]<br>[[Umuline Regular]], [[Insuman Rapid]], [[Winthrop Rapid]]<br><br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide] |
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− | | colspan="2" style="background:#cae1ff;text-align:center;font-size:9pt" | '''Use and Handling''' |
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|- |
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− | | style="background: |
+ | | colspan="2" style="background:#cae1ff; width:300px;text-align:center;font-size:9pt" | '''Use and Handling:''' |
⚫ | |||
|- |
|- |
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− | | style="background:aliceblue; width: |
+ | | colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left"| '''Shelf Life:''' 30 months |
− | | style="background:aliceblue; width: |
+ | |colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left" | '''Type:''' [[soluble]], [[clear]] |
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|- |
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− | |colspan="2" style="background:aliceblue;font-size:9pt;text-align:left" | ''' |
+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''When Opened:''' 6 weeks room temp. |
+ | |- |
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+ | |- |
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+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze,<br>May be used [[intravenously]] |
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− | </center> |
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− | <br> |
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+ | [[Image:actrapid.jpg|250px|thumb|left|Actrapid in 10 ml vial and 3 ml pen cartridge.]] |
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+ | |||
+ | <br clear=left> |
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{| |
{| |
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|style="height:1px;border:0;" colspan="3"| |
|style="height:1px;border:0;" colspan="3"| |
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|-valign="top" |
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− | |style="padding:5px;border:2px solid #b9f1f0;background-color:#f0f8ff;" width=" |
+ | |style="padding:5px;border:2px solid #b9f1f0;background-color:#f0f8ff;" width="100%"| |
'''Note that some countries have the brand name in U40 strength.''' |
'''Note that some countries have the brand name in U40 strength.''' |
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− | [[Image:actrapid.jpg|thumb|250px|right|Actrapid in 10 ml vial and 3 ml pen cartridge.]]Novo Nordisk's brand of fast-acting insulin<ref>{{cite web|url=http://emc.medicines.org.uk/medicine/15204/XPIL/Actrapid/ |title=Patient Information Leaflet-Actrapid|publisher=Novo Nordisk}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000424/WC500021655.pdf |title=Scientific Discussion-Actrapid|publisher=EMEA}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084240/www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref><ref>{{cite web|url=http://images1.wikia.nocookie.net/diabetesindogs/images/8/8d/Inshvialcmi6.pdf |title=Actrapid Information|publisher=Novo Nordisk}}</ref><ref>{{cite web|url=http://medguides.medicines.org.uk/document.aspx?name=Actrapid&use=Diabetes&preparation=1§ion=full |title=Actrapid|publisher=Medguides UK}}</ref>, known as [[Novolin R]] in North America<ref>{{cite web|url=http://www.revolutionhealth.com/drugs-treatments/novolin-r |title=Novolin R|publisher=Revolution Health}}</ref>. |
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− | + | Novo Nordisk's brand of fast-acting insulin, <ref>{{cite web|url=http://emc.medicines.org.uk/medicine/15204/XPIL/Actrapid/ |title=Patient Information Leaflet-Actrapid|publisher=Novo Nordisk}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000424/WC500021655.pdf |title=Scientific Discussion-Actrapid|publisher=EMEA}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084240/www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref><ref>{{cite web|url=http://images1.wikia.nocookie.net/diabetesindogs/images/8/8d/Inshvialcmi6.pdf |title=Actrapid Information|publisher=Novo Nordisk}}</ref><ref>{{cite web|url=http://medguides.medicines.org.uk/document.aspx?name=Actrapid&use=Diabetes&preparation=1§ion=full |title=Actrapid|publisher=Medguides UK}}</ref> known as [[Novolin R]] in North America. <ref>{{cite web|url=http://www.revolutionhealth.com/drugs-treatments/novolin-r |title=Novolin R|publisher=Revolution Health}}</ref> |
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+ | Comparable insulins made by others are: [[Huminsulin Normal]], [[Humulin R]] <ref>{{cite web|url=http://www.revolutionhealth.com/drugs-treatments/humulin-r |title=Humulin R Regular Human Insulin|publisher=Revolution Health}}</ref> and [[Humulin S]] <ref>{{cite web|url=http://emc.medicines.org.uk/medicine/13402/XPIL/Humulin+S+100IU+ml+solution+for+injection+in+vial/ |title=Patient Information Leaflet-Humulin S|publisher=Eli Lilly}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084230/www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Humulin_S.htm |title=Humulin S Prescribing Information}}</ref><ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/1071_LLY_Diabetes_RangeChar.pdf |title=Lilly EU/UK Product Sheet & Time Activity Profiles|publisher=Eli Lilly}}</ref> by [[Eli Lilly]], and [[Insuman Rapid]] <ref>{{cite web|url=http://images2.wikia.nocookie.net/diabetesindogs/images/8/82/Insuman_Rapid_patient_info_leaflet.pdf |title=Patient Information Leaflet-InsumanRapid|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084235/www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm |title=Prescribing Insuman Insulins}}</ref> and [[Winthrop Rapid]], both by [[Aventis]]. |
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⚫ | A [[short-acting]], soluble, non-suspended insulin produced from [[r-DNA/GE/GM]], [[bovine]], or [[porcine]] sources. Like all R or [[neutral]] insulins, nothing is added (suspensions) to alter the insulin's action or speed<ref> |
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⚫ | A [[short-acting]], soluble, non-suspended insulin produced from [[r-DNA/GE/GM]], [[bovine]], or [[porcine]] sources. Like all R or [[neutral]] insulins, nothing is added (suspensions) to alter the insulin's action or speed. <ref>{{cite web|url=http://web.archive.org/web/20061010214428/http://www.fda.gov/cder/foi/label/2003/18780scm078,slr067_Humalog_lbl.pd|publisher=Eli Lilly|title=Humulin R}}</ref> From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available. |
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⚫ | |||
− | + | While both R/neutral and [[semilente]] insulins are considered [[:Category:Fast-acting|fast-acting]], they differ in a few ways. As above, there's no [[suspension]] or buffer <ref name=Auburn>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Regular Insulin|author=DeRuiter, Jack|publisher=Auburn University}}</ref> in R/neutral; it's totally dissolved and [[soluble]], meaning it can safely be used [[:Category:Intravenous_use_YES|intravenously]]. <ref>{{cite web|title=Small Animal Clinical Pharmacology|author=Maddison, Jill E.,Page, Stephen W.,Church, David B.|year=2008|publisher=Saunders Ltd.|isbn=0702028584|page=510|url=http://www.amazon.com/Animal-Clinical-Pharmacology-Maddison-DipVetClinStud/dp/0702028584/ref=sr_1_1?s=books&ie=UTF8&qid=1296451134&sr=1-1}}</ref> |
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⚫ | The very small insulin particles in semilente insulin are suspended by [[Suspension#Zinc_suspension_insulins|zinc]]. <ref name=Auburn>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Lente|author=DeRuiter, Jack|publisher=Auburn University}}</ref> Semilente is [[cloudy]], has an acetate buffer and cannot be used [[:Category:Intravenous_use_NO|intravenously]]. |
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⚫ | R/Neutral insulin cannot be reliably mixed with [[Lente]] or [[Ultralente]] insulins<ref>{{cite web|url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=7192205 |title=Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente |year=1980|publisher=Diabetes Care}}<br>Note--in 1980, there |
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+ | |||
⚫ | R/Neutral insulin cannot be reliably mixed with [[Lente]] or [[Ultralente]] insulins. <ref>{{cite web|url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=7192205 |title=Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente |year=1980|publisher=Diabetes Care}}<br>Note--in 1980, there were no [[r-DNA/GE/GM]] insulins </ref><ref>{{cite web|url=http://web.archive.org/web/20080526072116/http://www.diabetes.org/rg2005/insulin.jsp |title=Resource Guide |year=2005|publisher=American Diabetes Association}}</ref> Semilente can; the ratio of 3 parts [[semilente]] insulin to 7 parts [[ultralente]] insulin produces [[Lente]] insulin. <ref name=Auburn>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Lente Insulin|author=DeRuiter, Jack|publisher=Auburn University}}</ref> |
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==R/Neutral Insulins== |
==R/Neutral Insulins== |
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! width="200"align="center" style="background:aliceblue;"| |
! width="200"align="center" style="background:aliceblue;"| |
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[[Bovine]]/[[Beef]] |
[[Bovine]]/[[Beef]] |
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− | !!width="300" align="center" style="background:ivory;"|[[Hypurin Bovine |
+ | !!width="300" align="center" style="background:ivory;"|[[Hypurin Bovine Neutral]]<br> [[Betasint Bovine Corriente]] |
|- |
|- |
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! width="200"align="center" style="background:aliceblue;"| |
! width="200"align="center" style="background:aliceblue;"| |
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[[Bovine]]/[[Beef]] |
[[Bovine]]/[[Beef]] |
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− | !!width="300" align="center" style="background:#dcdcdc"|[[Iletin R]] (No longer produced.)<br>[[Hypurin Vet Neutral]] (No longer produced.) |
+ | !!width="300" align="center" style="background:#dcdcdc"|[[Iletin R]] (No longer produced.)<br>[[Hypurin Vet Neutral]] (No longer produced.)<br>[[Insuvet Neutral]] (No longer produced.) |
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! width="200"align="center" style="background:aliceblue;"| |
! width="200"align="center" style="background:aliceblue;"| |
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! width="200"align="center" style="background:aliceblue;"| |
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[[R-DNA]] |
[[R-DNA]] |
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− | + | !width="300" align="center" style="background:ivory;"|[[Actrapid]], [[Huminsulin Normal]]<br>[[Humulin C]], [[Humulin R]]<br>[[Humulin Regular]], [[Humulina Regular]]<br>[[Humuline R]], [[Humuline Regular]]<br> [[Humulin S]], [[Insuman Rapid]]<br>[[Novolin R]], [[Umuline Rapide]]<br> [[Umuline Regular]], [[Winthrop Rapid]]<br>[[Humulin ReliOn R]] |
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+ | |- |
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+ | !width="200" align="center" style="background:aliceblue;"|[[R-DNA]] |
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+ | !width="300" slign="center" style="background:#dcdcdc;"|[[ReliOn/Novolin R]] (No longer produced.) |
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==References== |
==References== |
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+ | {{Reflist|colwidth=30em}} |
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− | <references/> |
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+ | |||
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*[http://images2.wikia.nocookie.net/__cb20100821055615/diabetesindogs/images/0/0a/NACDS_insulin_chart.pdf NACDS-Insulin Chart-Page 2] |
*[http://images2.wikia.nocookie.net/__cb20100821055615/diabetesindogs/images/0/0a/NACDS_insulin_chart.pdf NACDS-Insulin Chart-Page 2] |
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*[http://www.leedsth.nhs.uk/sites/diabetes/insular/InsulinGuide.php Leeds NHS UK-Insulin Guide] |
*[http://www.leedsth.nhs.uk/sites/diabetes/insular/InsulinGuide.php Leeds NHS UK-Insulin Guide] |
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− | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1687043/?page=1 Insulin therapy for dogs and cats |
+ | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1687043/?page=1 Insulin therapy for dogs and cats] Dowling, Patricia, Canadian Veterinary Journal, September 1995<br>A discussion of regular/neutral/normal insulins. |
+ | {|align="center" width="650" |
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− | A discussion of regular/neutral/normal insulins. |
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+ | !||||Related Pages|| |
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+ | |- |
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+ | |[[Image:Rtap.gif|120px]] |
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+ | |[[Image:HumilinLILLY.jpg|120px]] |
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+ | |[[Image:21944f.png|120px]] |
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+ | |[[Image:Rtap.gif|120px]] |
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+ | |[[Image:DSC02818.jpg|120px]] |
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+ | |- |
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+ | |<center>[[Humulin ReliOn R]]</center> |
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+ | |<center>[[Humulin R]]</center> |
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+ | |<center>[[Humulin S]]</center> |
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+ | |<center>[[Winthrop Rapid]]</center> |
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+ | |<center>[[Insuman Rapid]]</center> |
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+ | |} |
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+ | [[Category:GE R]] |
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[[Category:Insulins]] |
[[Category:Insulins]] |
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[[Category:Novo Nordisk]] |
[[Category:Novo Nordisk]] |
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[[Category:Meta-cresol]] |
[[Category:Meta-cresol]] |
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[[Category:Content]] |
[[Category:Content]] |
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+ | [[Category:Currently marketed insulins]] |
Latest revision as of 23:26, 23 May 2012
Actrapid | |
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R, Neutral by Novo Nordisk | |
short-acting | |
r-DNA/GE/GM | |
U40, U100 | none |
Action in dogs:
| |
Line: Novo | |
Also known as: Novolin R, ReliOn/Novolin R | |
Similar to: Huminsulin Normal, Humulin C Humulin R, Humuline R, Humulin Regular Humulina Regular, Humuline Regular, Humulin S Humulin ReliOn R, Umuline Rapide Umuline Regular, Insuman Rapid, Winthrop Rapid Names of Lilly r-DNA/GE/GM insulins worldwide | |
Use and Handling: | |
Shelf Life: 30 months | Type: soluble, clear |
When Opened: 6 weeks room temp. | |
In Pen: 6 weeks room temp. | |
Notes: Protect from light and heat Do Not Freeze, May be used intravenously |
Note that some countries have the brand name in U40 strength. |
Novo Nordisk's brand of fast-acting insulin, [2][3][4][5][6] known as Novolin R in North America. [7]
Comparable insulins made by others are: Huminsulin Normal, Humulin R [8] and Humulin S [9][10][11] by Eli Lilly, and Insuman Rapid [12][13] and Winthrop Rapid, both by Aventis.
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [14] From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [16]
The very small insulin particles in semilente insulin are suspended by zinc. [15] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [17][18] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [15]
R/Neutral Insulins[]
R/Neutral Insulins | |
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All Short acting All soluble | |
Hypurin Bovine Neutral Betasint Bovine Corriente | |
Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
Iletin I R (No longer produced.) | |
Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Actrapid Information. Novo Nordisk.
- ↑ Actrapid. Medguides UK.
- ↑ Novolin R. Revolution Health.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Patient Information Leaflet-InsumanRapid. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
- ↑ Humulin R. Eli Lilly.
- ↑ 15.0 15.1 15.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid
<ref>
tag; name "Auburn" defined multiple times with different content Cite error: Invalid<ref>
tag; name "Auburn" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care (1980).
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
More Information[]
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK-Insulin Guide
- Insulin therapy for dogs and cats Dowling, Patricia, Canadian Veterinary Journal, September 1995
A discussion of regular/neutral/normal insulins.
Related Pages | ||||
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