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*[http://images2.wikia.nocookie.net/__cb20100821055615/diabetesindogs/images/0/0a/NACDS_insulin_chart.pdf NACDS-Insulin Chart-Page 2] |
*[http://images2.wikia.nocookie.net/__cb20100821055615/diabetesindogs/images/0/0a/NACDS_insulin_chart.pdf NACDS-Insulin Chart-Page 2] |
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*[http://www.leedsth.nhs.uk/sites/diabetes/insular/InsulinGuide.php Leeds NHS UK-Insulin Guide] |
*[http://www.leedsth.nhs.uk/sites/diabetes/insular/InsulinGuide.php Leeds NHS UK-Insulin Guide] |
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| − | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1687043/?page=1 Insulin therapy for dogs and cats] Dowling |
+ | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1687043/?page=1 Insulin therapy for dogs and cats] Dowling, Patricia, Canadian Veterinary Journal, September 1995 |
A discussion of regular/neutral/normal insulins. |
A discussion of regular/neutral/normal insulins. |
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Revision as of 00:18, 7 November 2010
| Actrapid | |
|---|---|
| R, Neutral by Novo Nordisk | |
| short-acting | |
| r-DNA/GE/GM | |
| U40, U100 | none |
Action in dogs:
| |
| Line: Novo | |
| Also known as: Novolin R, ReliOn/Novolin R | |
| Similar to: Huminsulin Normal, Humulin C Humulin R, Humuline R, Humulin Regular Humulina Regular, Humuline Regular, Humulin S Humulin ReliOn R, Umuline Rapide Umuline Regular, Insuman Rapid, Winthrop Rapid Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 30 months | Type: soluble, clear |
| When Opened: 6 weeks room temp. | |
| In Pen: 6 weeks room temp. | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously | |
Actrapid in 10 ml vial and 3 ml pen cartridge.
|
Note that some countries have the brand name in U40 strength. | ||
Novo Nordisk's brand of fast-acting insulin [2][3][4][5][6], known as Novolin R in North America [7].
Comparable insulins made by others are: Huminsulin Normal, Humulin R [8] and Humulin S [9][10][11] by Eli Lilly, and Insuman Rapid [12][13] and Winthrop Rapid, both by Aventis.
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed [14] From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.
The very small insulin particles in semilente insulin are suspended by zinc [16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins [17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin [19].
R/Neutral Insulins
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral, Insuvet Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Actrapid Information. Novo Nordisk.
- ↑ Actrapid. Medguides UK.
- ↑ Novolin R. Revolution Health.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Patient Information Leaflet-InsumanRapid. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
- ↑ Humulin R. Eli Lilly.
- ↑ DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care (1980).
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ Resource Guide. American Diabetes Association (2005).
- ↑ DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.
More Information
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK-Insulin Guide
- Insulin therapy for dogs and cats Dowling, Patricia, Canadian Veterinary Journal, September 1995
A discussion of regular/neutral/normal insulins.