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*[[Humulin R]] |
*[[Humulin R]] |
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*[[Humulin Regular]] |
*[[Humulin Regular]] |
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+ | *[[Humulin ReliOn R]] |
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*[[Humulin S]] |
*[[Humulin S]] |
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*[[Humulina Regular]] |
*[[Humulina Regular]] |
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[[R-DNA]] |
[[R-DNA]] |
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− | !!width="300" align="center" style="background:ivory;"|[[Actrapid]], [[Huminsulin Normal]]<br>[[Humulin C]], [[Humulin R]]<br>[[Humulin Regular]], [[Humulina Regular]]<br>[[Humuline R]], [[Humuline Regular]]<br> [[Humulin S]], [[Insuman Rapid]]<br>[[Novolin R]], [[ReliOn/Novolin R]]<br>[[Umuline Rapide]], [[Umuline Regular]]<br> [[Winthrop Rapid]] |
+ | !!width="300" align="center" style="background:ivory;"|[[Actrapid]], [[Huminsulin Normal]]<br>[[Humulin C]], [[Humulin R]]<br>[[Humulin Regular]], [[Humulina Regular]]<br>[[Humuline R]], [[Humuline Regular]]<br> [[Humulin S]], [[Insuman Rapid]]<br>[[Novolin R]], [[ReliOn/Novolin R]]<br>[[Umuline Rapide]], [[Umuline Regular]]<br> [[Winthrop Rapid]], [[Humulin ReliOn R]] |
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Revision as of 18:38, 3 September 2010
Actrapid | |
R,Neutral by Novo Nordisk | |
short-acting | r-DNA/GE/GM |
U40, U100 | none |
Line | Novo |
Also known as | Novolin R, ReliOn/Novolin R |
Similar to | |
Action in dogs |
|
Use and Handling | |
---|---|
Type | soluble |
Shelf Life | 30 months |
When opened | 6 weeks room temp. |
In pen | 6 weeks room temp. |
Notes |
|
Note that some countries have the brand name in U40 strength. |
Novo Nordisk's brand of fast-acting insulin[2][3][4][5][6], known as Novolin R in North America[7].
Comparable insulins made by others are: Huminsulin Normal, Humulin R[8] and Humulin S[9][10][11] by Eli Lilly, and Insuman Rapid[12][13] and Winthrop Rapid, both by Aventis.
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed[14] From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer[15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.
The very small insulin particles in semilente insulin are suspended by zinc[16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins[17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin[19].
R/Neutral Insulins
R/Neutral Insulins | |
---|---|
All Short acting All soluble | |
Hypurin Bovine Neutral, Insuvet Neutral Betasint Bovine Corriente | |
Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) | |
Iletin I R (No longer produced.) | |
Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, ReliOn/Novolin R Umuline Rapide, Umuline Regular Winthrop Rapid, Humulin ReliOn R |
References
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Actrapid Information. Novo Nordisk.
- ↑ Actrapid. Medguides UK.
- ↑ Novolin R. Revolution Health.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Patient Information Leaflet-InsumanRapid. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
- ↑ FDA-Humulin R
- ↑ DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
- ↑ Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care (1980).
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ Resource Guide. American Diabetes Association (2005).
- ↑ DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.
More Information
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK-Insulin Guide
- Insulin therapy for dogs and cats-Dowling-Canadian Veterinary Journal-September 1995
A discussion of regular/neutral/normal insulins.