Changes: Actrapid

Revision as of 00:30, 12 June 2010

Use and Handling
Actrapid
R,Neutral by Novo Nordisk
short-acting	r-DNA/GE/GM
U40, U100	none
Line	Novo
Also known as	Novolin R, ReliOn/Novolin R
Similar to	Huminsulin Normal Humulin C Humulin R Humulin Regular Humulin S Humulina Regular Humuline R Humuline Regular Insuman Rapid Umuline Rapide Umuline Regular Winthrop Rapid Names of Lilly r-DNA/GE/GM insulins worldwide
Action in dogs	onset 10-30 minutes, peak 1-5h, duration 4-10h^[1]
Type	soluble
Shelf Life	30 months
When opened	6 weeks room temp.
In pen	6 weeks room temp.
Notes	protect from light and heat Do Not Freeze May be used intravenously

Actrapid in 10 ml vial and 3 ml pen cartridge.


Note that some countries have the brand name in U40 strength.

Novo Nordisk's brand of fast-acting insulin^[2]^[3]^[4]^[5]^[6], known as Novolin R in North America^[7].

Comparable insulins made by others are: Huminsulin Normal, Humulin R^[8] and Humulin S^[9]^[10]^[11] by Eli Lilly, and Insuman Rapid^[12]^[13] and Winthrop Rapid, both by Aventis.

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed^[14] From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer^[15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.

The very small insulin particles in semilente insulin are suspended by zinc^[16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins^[17]^[18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin^[19].

R/Neutral Insulins

R/Neutral Insulins
	All Short acting All soluble
Bovine/Beef	Hypurin Bovine Neutral, Insuvet Neutral Betasint Bovine Corriente
Bovine/Beef	Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.)
Bovine/Beef Porcine/Pork	Iletin I R (No longer produced.)
Porcine/Pork	Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO
Porcine/Pork	Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.)
R-DNA	Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, ReliOn/Novolin R Umuline Rapide, Umuline Regular Winthrop Rapid

References

More Information

A discussion of regular/neutral/normal insulins.

[1] Insulins-North American Veterinary Conference

[2] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Actrapid

[3] EMEA Scientific Discussion-Actrapid

[4] Prescribing Novo Insulins

[5] Actrapid Information from Novo

[6] Actrapid-Medguides UK

[7] Novolin R

[8] Humulin R Regular Human Insulin

[9] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin S

[10] Humulin S Prescribing Information

[11] Lilly EU/UK Product Sheet & Time Activity Profiles

[12] Electronic medicines Compendium (EMC) UK-Patient Information Leaflet-InsumanRapid

[13] Prescribing Insuman Insulins

[14] FDA-Humulin R

[15] Auburn University:Insulin Preparations-Regular Insulin

[16] Auburn University: Insulin Preparations-Lente

[17] Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GM Lente insulins

[18] Resource Guide 2005-American Diabetes Association

[19] Auburn University: insulin Preparations-Lente Insulin

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@@ Line 73: / Line 73: @@
 ! width="200"align="center" style="background:aliceblue;"|
 [[Bovine]]/[[Beef]]
-!!width="300" align="center" style="background:azure;"|[[Hypurin Bovine Neutral]], [[Insuvet Neutral]]<br>[[Betasint Bovine Corriente]]
+!!width="300" align="center" style="background:ivory;"|[[Hypurin Bovine Neutral]], [[Insuvet Neutral]]<br>[[Betasint Bovine Corriente]]
 |-
 ! width="200"align="center" style="background:aliceblue;"|
@@ Line 85: / Line 85: @@
 ! width="200"align="center" style="background:aliceblue;"|
 [[Porcine]]/[[Pork]]
-!!width="300" align="center" style="background:azure;"|[[Betasint Porcine Corriente]]<br>[[Hypurin Porcine Neutral]]<br>[[Hypurin Pork Regular]]<br>[[Maxirapid CHO]]
+!!width="300" align="center" style="background:ivory;"|[[Betasint Porcine Corriente]]<br>[[Hypurin Porcine Neutral]]<br>[[Hypurin Pork Regular]]<br>[[Maxirapid CHO]]
 |-
 ! width="200"align="center" style="background:aliceblue;"|
@@ Line 93: / Line 93: @@
 ! width="200"align="center" style="background:aliceblue;"|
 [[R-DNA]]
-!!width="300" align="center" style="background:azure;"|[[Actrapid]], [[Huminsulin Normal]]<br>[[Humulin C]],  [[Humulin R]]<br>[[Humulin Regular]], [[Humulina Regular]]<br>[[Humuline R]], [[Humuline Regular]]<br> [[Humulin S]],  [[Insuman Rapid]]<br>[[Novolin R]],  [[ReliOn/Novolin R]]<br>[[Umuline Rapide]], [[Umuline Regular]]<br> [[Winthrop Rapid]]
+!!width="300" align="center" style="background:ivory;"|[[Actrapid]], [[Huminsulin Normal]]<br>[[Humulin C]],  [[Humulin R]]<br>[[Humulin Regular]], [[Humulina Regular]]<br>[[Humuline R]], [[Humuline Regular]]<br> [[Humulin S]],  [[Insuman Rapid]]<br>[[Novolin R]],  [[ReliOn/Novolin R]]<br>[[Umuline Rapide]], [[Umuline Regular]]<br> [[Winthrop Rapid]]
 |}