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Changes: Actraphane 40/60

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[[Image:40_60.jpg|thumb|left|300px|Time activity profile for Actraphane 40/60.]]
  
[[Image:40_60.jpg|thumb|left|300px|Time activity profile for Actraphane 40/60.]]
 
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An intermediate-acting, mixed insulin<ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm Prescribing Novo Insulins]</ref> of 40% R/neutral insulin and 60% NPH/isophane insulin<ref>[http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20H)/HUMULIN.html RxMed-Humulin 40/60]</ref> made by [[Novo Nordisk]]. Mixtard 40<ref>[http://www.emea.europa.eu/humandocs/PDFs/EPAR/mixtard/226802en6.pdf EMEA Scientific Discussion-Mixtard]</ref> contains 60% [[isophane]] insulin crystals.
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An intermediate-acting, mixed insulin<ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm Prescribing Novo Insulins]</ref> of 40% R/neutral insulin and 60% NPH/isophane insulin<ref>[http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20H)/HUMULIN.html RxMed-Humulin 40/60]</ref> made by [[Novo Nordisk]]. Mixtard 40<ref>[http://diabetesindogs.wikia.com/wiki/Actraphane_30/70 EMEA Scientific Discussion-Mixtard]</ref> contains 60% [[isophane]] insulin crystals.
   
 
This insulin is similar to Lilly's [[Humulina 40/60]], [[Humulin M4]], [[Humuline 40/60]], and [[Huminsulin Profil IV]], to Novo's Penmix 40 and Mixtard 40, which was was discontinued December 31, 2007.<ref>[http://www.ukmicentral.nhs.uk/therapeu/pace/PACE0604.pdf Insulin Discontinuations-UK]</ref><ref>[http://www.yorkshirediabetes.com/downloads/A4Humandis.pdf Chart of Discontinued Novo Human Insulins]</ref> It is also similar to the discontinued North American offering of Lilly-[[Humulin 40/60]].
  
This insulin is similar to Lilly's [[Humulina 40/60]], [[Humulin M4]], [[Humuline 40/60]], and [[Huminsulin Profil IV]], to Novo's Penmix 40 and Mixtard 40, which was was discontinued December 31, 2007.<ref>[http://www.ukmicentral.nhs.uk/therapeu/pace/PACE0604.pdf Insulin Discontinuations-UK]</ref><ref>[http://www.yorkshirediabetes.com/downloads/A4Humandis.pdf Chart of Discontinued Novo Human Insulins]</ref> It is also similar to the discontinued North American offering of Lilly-[[Humulin 40/60]].
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[[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
  
[[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
   
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For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70<ref>[http://www.remedyfind.com/treatments/0/346/Insulin:%20Humulin%2010/90%20etc.%20(R%20Human;%20NPH%20Insulin) Humulin 10/90-NPH;R Human Insulin Remedyfind.com]</ref>. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
 +
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
   
 
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
  
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

Revision as of 12:37, 13 June 2010

Actraphane 40/60
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Mixtard 40, Penmix 40[1]
Similar to  


Names of Lilly r-DNA/GE/GM insulins worldwide

Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
Notes  
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use cartridges/pens.


40 60

Time activity profile for Actraphane 40/60.


An intermediate-acting, mixed insulin[2] of 40% R/neutral insulin and 60% NPH/isophane insulin[3] made by Novo Nordisk. Mixtard 40[4] contains 60% isophane insulin crystals.

This insulin is similar to Lilly's Humulina 40/60, Humulin M4, Humuline 40/60, and Huminsulin Profil IV, to Novo's Penmix 40 and Mixtard 40, which was was discontinued December 31, 2007.[5][6] It is also similar to the discontinued North American offering of Lilly-Humulin 40/60.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:


Non-Analog Mixed Insulins
Intermediate acting All Intermediate-acting
Expressed As Expressed As Insulin Is
10/90 90/10 10% R/Neutral Insulin
90% NPH/Isophane Insulin
20/80 80/20 20% R/Neutral Insulin
80% NPH/Isophane Insulin
30/70 70/30 30% R/Neutral Insulin
70% NPH/Isophane Insulin
40/60 60/40 40% R/Neutral Insulin
60% NPH/Isophane Insulin
50/50 50/50 50% R/Neutral Insulin
50% NPH/Isophane Insulin


References

  1. ↑ Medsafe NZ Penmix 40
  2. ↑ Prescribing Novo Insulins
  3. ↑ RxMed-Humulin 40/60
  4. ↑ EMEA Scientific Discussion-Mixtard
  5. ↑ Insulin Discontinuations-UK
  6. ↑ Chart of Discontinued Novo Human Insulins
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