Actraphane 30/70

Actraphane 30/70
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting	r-DNA/GE/GM
U40, U100	isophane
Line	Novo
Also known as	Mixtard 30, Novolin 70/30, Novolin 30R, Penmix 30,  ReliOn/Novolin 70/30
Similar to	Huminsulin Profil III Humulin 3/7 Humulin 30/70 Humulin 70/30 Humulin M3 Humulin Mix 30/70 Humulina 30/70 Humuline 30/70 Insuman Comb 30 Profil 30 Umuline Profil 30 Winthrop Comb 30 Names of Lilly r-DNA/GE/GM insulins worldwide
Action in dogs	onset 0.5-3h, peak 2-10h, duration 4-24h
Use and Handling
Type	cloudy
Shelf Life	30 months
When opened	6 weeks room temp.
In pen	6 weeks room temp.
Notes	protect from light and heat Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously

Time activity profile for Actraphane 30/70.

Note that some countries have the brand name in U40 strength.

Novo Nordisk's brand name for 30% R/neutral insulin and 70% NPH/isophane crystal insulin. This is an intermediate-acting insulin.

Other comparable insulins are: Novolin 70/30, Humulin 70/30, Mixtard 30 Humulin M3, Umuline Profil 30, Huminsulin Profil III, Humulina 30/70, Humuline 30/70, Insuman Comb 30, Winthrop Comb 30 and ReliOn/Novolin 70/30.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

Non-Analog Mixed Insulins
	All Intermediate-acting

Expressed As	Expressed As	Insulin Is
10/90	90/10	10% R/Neutral Insulin 90% NPH/Isophane Insulin
20/80	80/20	20% R/Neutral Insulin 80% NPH/Isophane Insulin
30/70	70/30	30% R/Neutral Insulin 70% NPH/Isophane Insulin
40/60	60/40	40% R/Neutral Insulin 60% NPH/Isophane Insulin
50/50	50/50	50% R/Neutral Insulin 50% NPH/Isophane Insulin