Actraphane 20/80 | |
---|---|
R/Neutral/NPH/Isophane Mix by Novo Nordisk | |
intermediate-acting | |
r-DNA/GE/GM | |
U100 | isophane |
Action in dogs:
| |
Line: Novo | |
Also known as: Mixtard 20, Penmix 20 | |
Similar to: Huminsulin Profil II, Humulin 20/80, Humulina 20/80, Humuline 20/80, Humulin M2, Profil II, Humulin M, Umuline Profil 20, Profil 20 Humulin 80/20 Names of Lilly r-DNA/GE/GM insulins worldwide | |
Use and Handling: | |
Shelf Life: 30 months | Type: cloudy |
When Opened: 6 weeks room temp. | |
In Pen: 6 weeks room temp. | |
Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [1] |
Novo Nordisk's brand name for its 20% R/neutral and 80% NPH/isophane crystal [2] insulin which is intermediate-acting.
Another comparable insulin, also Novo-made was Mixtard 20 [2][3][4]. Eli Lilly produced a comparable insulin called Humulin M2 [5]; it was discontinued in the EU & UK in July, 2004. [6] Humulin 20/80, made by Lilly for the North American market, is also discontinued. Lilly's names for this insulin sold elsewhere are Huminsulin Profil II, Umuline Profil 20, Humuline 20/80, Humulina 20/80, and in some places, Humulin M.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
Non-Analog Mixed Insulins | ||
---|---|---|
All Intermediate-acting | ||
Insulin Is | Expressed As | Expressed As |
10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ 2.0 2.1 Scientific Discussion Actraphane. EMEA. Cite error: Invalid
<ref>
tag; name "EMEA" defined multiple times with different content - ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Lilly EU/UK Product Names & Time Activity Profiles. Eli Lilly.
- ↑ Withdrawal of Humulin M2. Pharma Journal (July 2004).